| SalesforceSalesforce.com: The Customer Success Platform To Grow Your Business | Internet | San Francisco | CA | > $1B |
| SalesforceForce.com - Create Mobile Apps for Your Business - Salesforce.com | Internet | San Francisco | CA | > $1B |
| | Information Technology and Services | New York | NY | $250 - 500M |
| | Internet | Palo Alto | CA | $100 - 250M |
| submarino.com.brdata-react-helmet="true">Submarino - Os Produtos que voc?? curte est??o aqui. Explore! | Internet | | | $100 - 250M |
| SketchUp3D modeling for everyone | SketchUp | Computer Software | Boulder | CO | $1 - 10M |
| SurveyGizmoSurveyGizmo | Professional Online Survey Software & Tools | Computer Software | Boulder | CO | $10 - 50M |
| | E-Learning | Sebastopol | CA | $10 - 50M |
| | Internet | London | UK | $1 - 10M |
| | Computer Software | Chicago | IL | $100 - 250M |
| | Computer Software | | | > $1B |
| Sage PaySimple, Flexible & Secure Payment Services with Sage Pay | Financial Services | London | | $50 - 100M |
| | Newspapers | Stockholm | Stockholms Lan | $100 - 250M |
| | Banking | Tokyo | Tokyo | $250 - 500M |
| | Internet | New York | NY | $1 - 10M |
| | Education Management | | | $10 - 50M |
| SolarWindsIT Management Software & Monitoring Tools | SolarWinds | Computer Software | | | > $1B |
| | Computer Software | San Francisco | CA | $1 - 10M |
| | Computer Software | Redwood City | CA | $10 - 50M |
| SolarCitySolar – Solar Energy Efficiency | SolarCity | Renewables & Environment | San Mateo | CA | $100 - 250M |
| Safe SchoolsSchool Safety Training, District Risk Management, School Safety - SafeSchools | Primary/Secondary Education | Silverton | OH | $0 - 1M |
| | Higher Education | St. Louis | MO | > $1B |
| | Computer Software | Calgary | AB | $500M - 1B |
| SciQuestJaggaer | Procurement Software & Cloud Based Business Automation ... | Computer Software | Cary | NC | $50 - 100M |
| | Online Media | Vancouver | BC | $1 - 10M |
| | Information Technology and Services | Southlake | TX | > $1B |
| SharethroughSharethrough - Native Advertising Software For Publishers | Marketing and Advertising | San Francisco | CA | $1 - 10M |
| Schedulicityng-bind="title">Schedulicity Online Scheduling | Book Appointments Online | Internet | Bozeman | MT | $1 - 10M |
| SprinklrSocial Media Management (SMM): Digital Transformation | Sprinklr | Information Technology and Services | New York | NY | $250 - 500M |
| | Education Management | Greenville | WI | $500M - 1B |
| Safeco InsuranceSafeco Auto Insurance, Car Insurance, Home Insurance and more | Safeco Insurance | Insurance | Boston | MA | > $1B |
| | Apparel & Fashion | New York | NY | $0 - 1M |
| | Real Estate | Emmonak | AK | $1 - 10M |
| SuitsupplyMen’s Suits, Jackets, Shirts, Trousers, and More | Suitsupply Online Store | Apparel & Fashion | Binghamton | NY | > $1B |
| StreamSendEmail Marketing | Email Newsletters | Behavioral Automation - StreamSend | Marketing and Advertising | Sacramento | CA | $0 - 1M |
| Schedulefly, Inc.Restaurant Staff Scheduling and Communication Software by Schedulefly | Internet | Raleigh | NC | |
| | Renewables & Environment | Fremont | CA | $50 - 100M |
| SalomonSALOMON Time to play - Choose your country | Sporting Goods | ANNECY CEDEX 9 FRANCE | | $500M - 1B |
| | Computer Software | | | $100 - 250M |
| SugarSyncCloud File Sharing, File Sync & Online Backup From Any Device | SugarSync | Computer Software | San Mateo | CA | $10 - 50M |
| SDL plcSDL: Language Translation & Content Management Company | Information Technology and Services | Maidenhead | England | > $1B |
| SWIFTSWIFT – The global provider of secure financial messaging services | Financial Services | | | > $1B |
| | Information Technology and Services | Santa Clara | CA | $1 - 10M |
| | Information Services | Charlottesville | VA | $100 - 250M |
| Sam Ash Music
Online Music Store, Guitars, Drums, Amps, DJ Equipment | SamAsh Music Direct
| Music | Hicksville | NY | $100 - 250M |
| | Higher Education | Gainesville | FL | $100 - 250M |
| | Publishing | | | $10 - 50M |
| Sierra ClubSierra Club Home Page: Explore, Enjoy, and Protect the Planet | Political Organization | San Francisco | CA | $100 - 250M |
| | Internet | San Francisco | CA | $1 - 10M |
| SmaatoMobile Advertising and App Monetization Platform - Smaato | Marketing and Advertising | San Francisco | CA | $1 - 10M |
| | Marketing and Advertising | Berlin | Berlin | $100 - 250M |
| Startup GrindStartup Grind | Global community for entrepreneurs | Startup Grind | Events Services | Mountain View | CA | $0 - 1M |
| | Leisure, Travel & Tourism | Holt | MI | $100 - 250M |
| | Financial Services | San Francisco | CA | $50 - 100M |
| SalesLoftSalesLoft - The Modern Sales Engagement Platform | Computer Software | | | $10 - 50M |
| SecurlyWeb Filtering & Parental Controls for Schools & Families - Securly | Internet | Santa Clara | CA | $0 - 1M |
| | Internet | New York | NY | $1 - 10M |
| SharpSpringSimple, Easy, Affordable Marketing Automation | SharpSpring | Marketing and Advertising | Gainesville | FL | $1 - 10M |
| | Financial Services | Glenview | IL | $250 - 500M |
| SmartlingSmartling Global Content Translation and Localization Solution | Information Technology and Services | New York | NY | $1 - 10M |
| SyscoSysco.com Splash Page | Food & Beverages | Houston | TX | > $1B |
| | Hospital & Health Care | Grand Rapids | MI | > $1B |
| | Higher Education | Greensburg | PA | $100 - 250M |
| SHAREGATEOffice 365 & SharePoint Migration & Management | Sharegate | Computer Software | MONTREAL | QC | $10 - 50M |
| | Retail | Fort Lauderdale | FL | $10 - 50M |
| ShopSociallyShopSocially Social Referral Marketing | Customer Loyalty Program | ShopSocially | Internet | Mountain View | CA | $1 - 10M |
| | Information Technology and Services | State College | PA | $10 - 50M |
| | Online Media | San Francisco | CA | $50 - 100M |
| | Marketing and Advertising | New York | NY | $1 - 10M |
| ShipwireLogistics, Supply Chain Management and Order Fulfillment Experts | Logistics and Supply Chain | Sunnyvale | CA | $10 - 50M |
| | Research | Menlo Park | CA | $500M - 1B |
| SubsplashSubsplash.com | Engage your audience like never before. | Computer Software | Seattle | WA | $0 - 1M |
| SumUpCredit Card Readers - Accept Card Payments including EMV and NFC | SumUp | Financial Services | Dublin | County Dublin | $1 - 10M |
| SafarilandLaw Enforcement Products | The SAFARILAND Group | Consumer Goods | Ontario | CA | $500M - 1B |
| SkytapSkytap | Run Traditional Enterprise Applications in the Cloud | Information Technology and Services | Seattle | WA | $10 - 50M |
| SalesforceAdvertising Software - CRM Targeting & Campaign Management - Salesforce.com | Internet | San Francisco | CA | > $1B |
| Smart FurnitureSmart Furniture | Home & Office Furniture Customized By You, On Demand - Smart Furniture | Furniture | Chattanooga | TN | $1 - 10M |
| | Marketing and Advertising | San Francisco | CA | $1 - 10M |
| | Computer Software | Okemos | MI | $10 - 50M |
| | Information Technology and Services | Shinjuku-ku | | $1 - 10M |
| | Internet | Westminster | CO | $100 - 250M |
| | Marketing and Advertising | | | $1 - 10M |
| SaasuSaasu - Online Accounting Software | Internet | Sydney | NSW | $1 - 10M |
| | Financial Services | Louisville | KY | $50 - 100M |
| SHIFT.comShift | The completely reimagined way to buy or sell a used car | Marketing and Advertising | Santa Monica | CA | $0 - 1M |
| | Marketing and Advertising | Sao Paulo | SP | $0 - 1M |
| | Computer Software | Lehi | UT | $1 - 10M |
| SmarshSmarsh Archiving Solution | Archiving & Compliance | Smarsh | Information Technology and Services | Portland | OR | $10 - 50M |
| | Internet | Waterloo | ON | $0 - 1M |
| | Education Management | New York | NY | $500M - 1B |
| | Semiconductors | Camarillo | CA | $250 - 500M |
| Surya
Surya | Rugs, Pillows, Wall Decor, Lighting, Accent Furniture, Throws, Bedding
| Consumer Goods | Calhoun | GA | $100 - 250M |
| SheroMagento, Shopify Plus, Bigcommerce Development Agency NY | Online Media | Poughkeepsie | NY | $0 - 1M |
| | Arts and Crafts | Stockholm | | $0 - 1M |
| | Computer Software | San Francisco | CA | |
| Salem Web NetworkSalem Web Network – Christian Advertising & Broadcasting - Salem Web Network | Internet | Richmond | VA | $10 - 50M |
| | Computer Software | Blumenau | SC | $500M - 1B |
| SmartShootPhotography & Video Production Professionals For Your Project | Internet | San Francisco | CA | $1 - 10M |
| SecureworksInformation Security Solutions, Managed Security Services | SecureWorks | Computer & Network Security | | | > $1B |
| | Information Technology and Services | Minneapolis | MN | $50 - 100M |
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